factors affecting biotransformation of drugs pdf

Factors affecting biotransformation of drugs pdf

FACTORS AFFECTING ORAL ABSORPTION y Disintegration of dosage form y Dissolution of particles y Chemical stability of drug y Stability of drug to enzymes y Motility and mixing in GI tract y Presence and type of food y Passage across GI tract wall y Blood flow to GI tract y Gastric emptying time y FORMULATION. BIOAVAILABILITY ? the proportion of the drug in a dosage form available to the …. Various factors are involved, both of skin and drug, which affects the availability of drug in the systemic circulation through the transdermal route and are essential to be considered during

Factors Affecting Phase I Stereoselective

Some factors affecting phencyclidine biotransformation by human liver and placenta. Some factors affecting phencyclidine biotransformation by human liver and placenta.. Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism).

PHARMACOKINETICS: Metabolism/Biotransformation (p.1) Drugs are eliminated from the body in two major ways: metabolism/biotransformation by the liver and/or excretion. Factors Affecting Drug Biotransformation K. W. RENTON Department of Pharmacology, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, NS, Canada Biotransformation of drugs to polar metabolites is a key step in the termination of action and the elimination of drugs used in thera- …

Pharmacology Lecture 6th Week Drug Metabolism

1/3 (33%) of all drugs are prescribed for them vrate of biotransformation of some drugs . Phase I metabolism (cytochrome P450 system) Drug oxidation, reduction and hydrolysis Decreases substantially with age Drugs that are metabolized through phase I have prolonged half-lives (Amitriptyline Barbiturates Diazepam Diphenhydramine Flurazepam Ibuprofen Labetalol Lidocaine) …. FACTORS AFFECTING ORAL ABSORPTION y Disintegration of dosage form y Dissolution of particles y Chemical stability of drug y Stability of drug to enzymes y Motility and mixing in GI tract y Presence and type of food y Passage across GI tract wall y Blood flow to GI tract y Gastric emptying time y FORMULATION. BIOAVAILABILITY ? the proportion of the drug in a dosage form available to the …. Pharmacology Lecture 6th Week January 17,2014 Biotransformation. Biotransformation - is the chemical modification (or modifications) made by an organism on a chemical compound.

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factors affecting biotransformation of drugs pdf

BIOTRANSFORMATION PowerPoint PPT Presentation

The most important factors affecting onset are pH of the tissue and pKa of the drug. The pH may drop in sites of infection, which causes onset to be delayed or even prevented. Clinically, there are no signi?cant differences in pKa among the amides, with the exception of bupivacaine, which has a slightly higher pKa and hence a slower onset of action. Proximity of the deposition of local. “Biotransformation ” should be used in preference to “drug metabolism”, and the word “metabolism” should probably be reserved to denote the biotransformation of materials essential to an adequate nutritional state. “Biotransformation” and “detoxication” are not synonyms: the product of a biotransformation may be more, not less, biologically active, or potent, than the. Factors Affecting Biotransformation of drugs: Factors Affecting Biotransformation of drugs Physicochemical properties of the drug Chemical factors 1) Enzyme induction 2) Enzyme inhibition 3) Environmental chemicals Biological factors 1) Strain differences 5) Species differences 2) Sex differences 6) Age 3) Diet 7) Altered physiologic

Introduction to Drug Metabolism SpringerLink

The half-life of a drug is the CLINICAL FACTORS AFFECTING HALF LIFE time it takes for its concentration in blood or plasma to The half-life can also be expressed in terms of decrease by half. The time required for any plasma the drug’s clearance and volume of distribution, concentration of drug to fall by 50% is known as half- life indicating that the drug’s half-life will change when.

1/3 (33%) of all drugs are prescribed for them vrate of biotransformation of some drugs . Phase I metabolism (cytochrome P450 system) Drug oxidation, reduction and hydrolysis Decreases substantially with age Drugs that are metabolized through phase I have prolonged half-lives (Amitriptyline Barbiturates Diazepam Diphenhydramine Flurazepam Ibuprofen Labetalol Lidocaine) ….

Pharmacology Lecture 6th Week January 17,2014 Biotransformation. Biotransformation - is the chemical modification (or modifications) made by an organism on a chemical compound.. Already at this stage, there are several individual factors that can affect drug response, such as the patient’s age, gastric pH, a high-fat diet, cardiovascular or digestive diseases, rate of gastric emptying and gastric motility. [3].

Regioselective biotransformation of CNS drugs and its Download book PDF. Drug Metabolism pp 243-268 Cite as. Factors that Influence Drug Biotransformation. Chapter. 1.3k Downloads; Keywords Drug Metabolism Species Difference Hepatic Drug Metabolism Purine Alkaloid Drug Biotransformation These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning …

Chapter 6 FACTORS THAT INFLUENCE DRUG BIOTRANSFORMATION

In vitro incubations of rat cytochrome P-450 (CYP) 2B1 isozyme with three chiral polychlorinated biphenyl (PCB) congeners (PCBs 45, 95, and 132) were performed to investigate factors affecting phase I stereoselective biotransformation.

  • UNIT I PHARMACOKINETICS SRM Institute of Science and
  • PHAR430- Factors affecting Biotransformation Flashcards
  • Introduction to Drug Metabolism SpringerLink
  • Factors affecting drug biotransformation.

 

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Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism).. The term 'drug metabolism' in its broadest sense may be considered as the absorption, distribution, biotransformation and excretion of drugs. To cover all these facets of drug metabolism in a single text is a voluminous task and therefore we have focused primarily on the biotransformation ….

Factors affecting rates of xenobiotic biotransformation

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factors affecting biotransformation of drugs pdf

1 Factors affecting rates of xenobiotic biotransformation •Intrinsic (chemical) factors •Extrinsic (host) factors –enzyme induction and inhibition. The most important factors affecting onset are pH of the tissue and pKa of the drug. The pH may drop in sites of infection, which causes onset to be delayed or even prevented. Clinically, there are no signi?cant differences in pKa among the amides, with the exception of bupivacaine, which has a slightly higher pKa and hence a slower onset of action. Proximity of the deposition of local.

Biological factors affecting toxic response Diseases •Acute and chronic liver injury such as hepatitis, cirrhosis, toxic hepatitis, porphyria, and liver tumors will affect the biotransformation. •Renal disease can cause disturbances in excretion of a chemical thus increasing its toxicity. •Severe heart diseases can increase toxicity of chemical by impairing the renal and hepatic. 5 Biotransformation of Xenobiotics Biological basis for xenobiotic metabolism: ! To convert lipid-soluble, non-polar, non-excretable forms of chemicals to water- Read more: Islamic Financial System Principles And Operations 2nd Edition Pdf.

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BIOTRANSFORMATION PowerPoint PPT Presentation

1. Pharmacology Lecture 6th Week Drug Metabolism
2. PHAR430- Factors affecting Biotransformation Flashcards
3. Factors affecting rates of xenobiotic biotransformation

Regioselective biotransformation of CNS drugs and its “Biotransformation ” should be used in preference to “drug metabolism”, and the word “metabolism” should probably be reserved to denote the biotransformation of materials essential to an adequate nutritional state. “Biotransformation” and “detoxication” are not synonyms: the product of a biotransformation may be more, not less, biologically active, or potent, than the. Factors that Influence Drug Biotransformation SpringerLink.

 

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